In English we say
He looks tired.
Which is an accurate way to say this in Spanish?
Se ve cansado.
Él parece cansado [EN: He appears tired]
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As @Danielillo commented, both are valid.
As @tac commented, we use to add a pronoun to the first version, either "lo" or "le". Being this second option perfectly valid, and as he said using "le" there, as well as in other situations, is known as "leismo".
All this said, I would like to take the advantage on your question to offer you some variants that you can use depending on your location. Maybe other users can add other variants.
In Andalucía and Extremadura, in Spain, I think that we would use your second option with the improvements also mentioned by @tac but we tend to pronounce it slightly different
Parece que e'tá cansao
We don't pronounce exactly the s sound in "está" and definitively we don't pronounce the d in cansado.
Specifically in Andalucía, we can use this variant
Parece que está reventao
And in Málaga, Andalucía, Spain, you can hear
Parece que está guarnío
Being both "reventao" and "guarnío" synonyms of "cansado" [tired].
Notice that in all examples I've omitted "él" at the beginning. It's not really necessary.